Annatto-E®

Pure Tocotrienol Vitamin E for Cardiovascular Health, Antioxidant Status, and Multi-System Support*

Key Performance Benefits

• Supports vitamin E status with clinically beneficial tocotrienol forms*

• Promotes metabolic and cardiovascular health*

• Supports antioxidant status and a healthy inflammatory response*

• Supports lung, skin, and eye health*

• Supports healthy bones*

What This Product Is

Annatto-E® delivers pure delta- and gamma-tocotrienols sourced from annatto (Bixa orellana), the richest known source of naturally occurring tocotrienols. Vitamin E consists of eight forms within two categories — tocotrienols and tocopherols — each with unique properties that influence function and effects on the body. Most conventional vitamin E supplements are rich in tocopherols (alpha-tocopherol in particular), yet the tocotrienol forms have unique effects across various body systems that make them desirable for supporting many aspects of health and overall wellness.*

Annatto-E® is made with DeltaGold®, containing 100% tocotrienols and 0% tocopherols. Available in two serving size options — 150 mg and 300 mg — to support flexible clinical dosing. Because tocopherols may potentially interfere with the clinical benefits of tocotrienols, it may be best to take Annatto-E® independently of any other supplement containing alpha-tocopherols, or to separate intake by at least 6 hours.*

Mechanism of Action

Antioxidant and Inflammatory Response Support

Tocotrienols support antioxidant status through potent free radical scavenging activity. Their unique molecular structure — featuring a shorter, unsaturated side chain compared to tocopherols — allows tocotrienols to distribute more efficiently in cell membranes. This antioxidant activity also supports a healthy inflammatory response throughout the body.*

Cardiovascular and Metabolic Health

Delta- and gamma-tocotrienols promote metabolic and cardiovascular health. The tocotrienol forms of vitamin E have demonstrated unique effects on cardiovascular markers and metabolic function, supporting healthy aging and overall metabolic wellness.*

Multi-System Support

The tocotrienols in Annatto-E® may support cardiovascular, skin, eye, bone, and lung health. This broad-spectrum activity across multiple body systems makes tocotrienol supplementation clinically relevant for the general population seeking comprehensive vitamin E support.*

Applications

• Individuals seeking to support vitamin E status with clinically beneficial tocotrienol forms*

• Those looking to promote cardiovascular and metabolic health*

• Individuals seeking antioxidant support and a healthy inflammatory response*

• Those looking to support skin, eye, lung, and bone health*

• Individuals seeking a tocopherol-free vitamin E option for optimal tocotrienol benefit*

Key Ingredients / Formula Highlights

DeltaGold® Tocotrienols (150 mg or 300 mg per softgel)

Sourced from annatto (Bixa orellana), the richest known source of naturally occurring tocotrienols. Contains 100% tocotrienols and 0% tocopherols in the delta and gamma forms for synergistic, clinically beneficial vitamin E support.*

Two Potency Options

Available as Annatto-E® 150 (150 mg per softgel) and Annatto-E® 300 (300 mg per softgel) to support flexible clinical dosing based on individual needs.

Clean Formula Design

Gluten-free, dairy-free, soy-free, and non-GMO.

Suggested Use

Take 1 softgel per day or as directed by your health-care practitioner.

Product Questions

What is the difference between tocotrienols and tocopherols?

Both are forms of vitamin E, but they have different structures and unique effects on the body. Most conventional supplements are rich in tocopherols, yet tocotrienols have distinct benefits across multiple body systems. Annatto-E® provides 100% tocotrienols and 0% tocopherols for optimal tocotrienol benefit.*

Why should tocotrienols be taken separately from tocopherols?

Although tocopherols may have beneficial effects on their own, they may potentially interfere with the clinical benefits of tocotrienols. For this reason, it may be best to take Annatto-E® independently of any other supplement containing alpha-tocopherols, or to separate the intake of each by at least 6 hours.*

How do I choose between the 150 mg and 300 mg options?

Both options deliver the same DeltaGold® tocotrienols in delta and gamma forms. The 300 mg option provides a higher potency for individuals who may benefit from increased tocotrienol support. Consult with your health-care practitioner to determine the appropriate serving size for your needs.*

Practitioner Reference

Annatto-E® is positioned within the Designs for Health Foundational Health category. Available as ANT150 (30 softgels, 150 mg) and ANT300 (30 softgels, 300 mg). This product is intended for use under the guidance of a licensed health-care practitioner.